Immune Support & EPM Supplements

Big Dee's has a large selection of Immune Support and EPM supplements to help aide your horse. Immune support can help horses with stressed immune systems or horses susceptible to illness from showing. Equine Protozoal Myeloecephalitis, or EPM, is a disease caused by the protozoa, Sarcoystis neurona which attacks the central nervous system of the horse causing muscle atrophy, asymmetry, loss of coordination, and several issues. If caught early, the EPM horse can be treated successfully, and maintained through supplements.

Horse Supplements - lowest prices

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HistAll H All Natural Respiratory Support

HistAll by Animed

Specially formulated for horses with allergies. 

Product Details:
Aids in suppression of anflammatory responses
Supports normal histamine levels
Supports healthy immune system
20 oz

Immusyn Powder 1 lb

Farnam Immusyn helps support normal immune function. With the aid of Glutasyn, which is a milk protein, it promotes the activity of glutathione. Glutathione is a naturally occuring protein and antioxidant found in almost every cell of the body.  

Product Details:

  • For all ages and breeds of horses
  • Supports overall wellbeing
  • Maintains a healthy immune system
  • Boosts immune system during strenuous activities
  • Aids in detoxifying
  • Made in the USA
  • Powder form

A 1 lb container is a 32 day supply for one horse.

Advanced Imm-Hance EQ 1.875 lb
Was: $56.95
SALE $21.00

Advanced Imm-Hance EQ by AniMed is a scientifically engineered equine nutritional product consisting of an advanced proprietary blend of yeast extracts and nutritional factors with PETerna. Imm-Hance provides support for a healthy immune system in horses. Imm-Hance also supports normal recovery time after athletic activity.

Product Details:

  • Provides support for a healthy immune system
  • Also promotes recovery after strenuous activity 


APF Pro Equine
$64.95 - $186.00

APF Pro Equine is the most advanced herbal formula for use in horse to protec the immune system and cellular metabolism.  APF Pro provides your horse a much needed ulcer fighting benefit while still providing the necessary stress protection.  Research has shown that Aralia can provide important protective benefits to fight against stress caused ulcers. 

Product Details:

  • Improved formula provides powerful anti-catabolic action to help build and maintain skeletal muscle
  • Increases resistance to stress induced gastric ulcers
  • Protects the immune system from long-term or intense stress
  • Optimizes glucose uptake and utlization in muscle cells
  • Promotes higher levels of ATP and CP in muscle cells
  • Improves utilization of lipids (fats) for long-term energy production
  • Improves and protects mitochondrial efficiency
  • Delays the onset of fatigue during exercise Improves recovery from physical exertion
  • Protects digestive function by providing sustained energy to the GI tract
  • Delivers powerful anti-oxidant activity to protect against free radical damage
  • Protects against the damaging effects of intense or chronic stress
Prolific Equine
$64.95 - $119.95

Prolific by Spectra Animal Health

Specially formulated for horses under stress. Profilic is a nutrient-dense spirulina tablet which provides nutritional support for stress and performance horses. Containing essential amino acids, chlorophyll, beta-carotene and other natural phytochemicals.

Product Details:

  • Contains essential gamma-linolenic fatty acid
  • Most digestible source of complete protein
  • Elevates activity of antioxidant enzymes
  • Stimulates production of interferon and IL-2 which activates the immune system
  • Anti-inflammatory
  • Helps improve red and white blood cell
  • Promotes a healthy coat
  • USDA organic
  • USP Verified
  • Free from herbicides, pesticides
  • Non-irradiated
24 Immune Support

#24 Immune Support by Silver Lining Herbs supports the immune system, which may aid in clearing up a wide range of seemingly unrelated issues. Everything you put into or onto your horse is used or not used by his body on a cellular level. Elements of foods and topical substances that are not used need to be evacuated from the body, which a healthy immune system is able to do via the liver, kidneys, blood, lymphatic, digestive system, skin, etc.

With all that we throw at our horses today from immunizations to pesticides, to reduced grazing and increased travel schedules their immune systems can easily become overwhelmed at the cleanup work required. #24 Immune Support provides the support that the immune system needs to work effectively.

Product Details:

  • May be beneficial in:
  • Supporting a healthy immune system
  • Maintaining body cells and tissues
  • Bacterial and fungal issues
  • Exposure to chlorinated water and pesticides
  • Blisters
  • Blood warts
  • Rough hair coat or won't shed normally
  • Lethargic, weak, not working to normal levels, or over-exerted when asked to
  • Lumps under tail
  • Supporting the normal detoxification process
  • Stress
  • Underweight
  • Pronounced abnormal wrinkles over eyes
  • Contains Approximately 60 scoops per bag.

Recommended use:1 level scoop per day for 1000-1200 lb horse

Active Ingredients: A proprietary blend of (Eleuthero, Garlic, Olive Leaf, Plantain, Red Clover, Rose Hips, Sarsparilla, Barberry, Echinacea, Parsley, Wheat Grass, Cascara and Licorice) 6898 mg per tbsp. Scoop included.

ImmuneSaver 1 lb

ImmuneSaver is a powerful immunity enhancer with demonstrated anti-inflammatory, anti-allergen, anti-microbial, anti-tumor, anti-ulcer, anti-oxidant and adaptogenic properties. Its unique, proprietary formula combines clinically proven ingredients to stimulate and strengthen the body's immune system naturally.

Product Details:

  • Boosts immune system
  • Maintains overall wellbeing
  • Powder form

1 lb size contains 50 scoops.

*This item cannot be shipped internationally

Ester C 1.5 lb
Was: $75.50
SALE $55.00

Ester-C by Peak Performance is a vitamin C supplement. Formulated to not upset the horse's stomach or cause ulcers and is 4 times more absorbable than regular vitamin C. Ester-Cis used to support normal lung function as well as boost immune defenses, support joint health and assist in allergy relief.

Product Details:

  • Contains no fillers or sugar.
  • Supports normal lung function
  • Boosts immune defenses
  • Promotes joint health
  • Assists in allergy relief

The 1.5 lb/0.68 kg size provides up to a 136 day supply for one horse and delivers 5,000 mg of Ester-C.


Sarstart EPM Treatment Gallon

SarStart by Sar Tec is an equine supplement used in the treatment of EPM symptoms in horses and a possible EPM prevention product. A liquid additive that can be easily mixed directly into a horse's feed.

Contains saponins (from yucca schidigera extract) that have been shown to kill protozoa in the digestive tracts of animals.


  • Liquid
  • Treats symptoms of EPM
  • Kills protozoa in the digestive tract

One gallon will last 42 treatment doses and 60-120 days on prevention dosage. 

Immune Plus 32 oz

Immune System Formula by Omega Alpha enhances the immune system function to combat pathogens. It does this by activating a number of immune system pathways with a synergistic combination of ingredients. It also combines restorative herbs to build back the body’s normal energy levels. Boosting the immune system is important for animals suffering from fatigue and other chronic ailments.

Immune Plus is manufactured under strict GMP standards. This information is not intended to diagnose or treat health conditions. We always recommend consultation with your veterinarian for proper diagnosis.

Product Details:

  • Supports normal immune system functions
  • All natural ingredients
  • Boost immune response
  • Increases the production and activity of white blood sells
  • Liquid
  • Maintains good health in horses
Pure C  1 lb
Pure C by Vita Flex is pure vitamin C in an affordable, easy-to-feed supplement . It contains pure ascorbic acid and is very palatable. Vitamin C is sometimes called the workhorse of the vitamins because it is required in hundreds of metabolic processes.

During periods of stress, intensive exercise, illness or injury your horse may require more vitamin C than the body can produce. The horse's body needs vitamin C to grow, maintain, and repair structural tissues. In addition, recent research has shown the need for vitamin C in producing specific proteins, such as collagen, and other structural elements of connective tissue.

Vitamin C is also an important helper nutrient, assisting in the absorption of iron and calcium, the formation of folic acid, and the metabolism of the amino acids tyrosine and tryptophan. The optimum long-term health of your horse rests upon a strong defense, against both external and internal threats. Vitamin C has long been noted for its support of the immune system. It is a potent antioxidant nutrient, and eliminates damaging free radicals produced within the body during oxidation and inflammation.

The 1 lb size provides up to a 64 day supply for one horse on maintenance.

Accel Lifetime  5 lb

Accel Lifetime is a comprehensive multi-vitamin and mineral supplement, with GlutaSyn for patented immune and antioxidant support. Accel Lifetime delivers optimal levels of essential water soluble and fat soluble vitamins, chelated and conventional minerals, trace minerals, amino acids plus probiotics and yeast cultures for the digestive system. It is the ideal one-step supplement providing a strong nutritional foundation for all horses.

Product Details:

  • Immune and antioxidant support
  • Excellent source of vitamins and minerals
  • Digestive support

A 5 lb container is an 80 day supply for one horse.

Total Immune Blast  180 Day Supply

Total Immune Blast by Ramard Inc is for horses with stressed immune systems or horses stabled at race tracks or show facilities where they are susceptible to illness. Horses which have a stressed immune system from training, environmental changes or breeding season, will also benefit greatly.

Product Details:

  • Helps your horse bounce back quickly.
  • Supports normal immune response.
  • May help your horse’s body fight the damaging effects of free radicals.
  • Superior for respiratory issues such as colds and runny nose. Supports your horses ability fight off infections.

Feed one scoop (0.6 oz) per horse per day. The 1.12 lb/510 g size provides up to a 30 day supply for one horse.

Also comes in 30 Days Supply.

Epic Daily Feed Supplement For Horses 4.4 lb

Epic Daily by Bioniche is a daily feed supplement that provides triple action support for respiratory, immune system and gastro-intestinal. Formulated for horses under stress such as, young horses in training, heavy competition schedules, transporting to new venues or pre-sale preparation. Excellent when horses are entering new environments: sale barns, commingling and stall housing.

Product Details:

  • Aids in digestive health
  • Egg Protein In Complexes in a Rice Bran Base
  • Omega 3 and Omega 6 fatty acids
  • Lactobacillus acidophilus
  • Enterococcus faecium
  • Made in the USA
  • Supplied scoop holds approximately 25 g of supplement (40 day supply).
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